α-Mangostin suppresses 12-o-tetradecanoylphorbol-13- acetate-mediated matrix metalloproteinase-9 expression in human osteosarcoma cells U2OS
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چکیده
منابع مشابه
Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells
PURPOSE Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in cancer cell invasion. Crotonis fructus (CF), the mature fruits of Croton tiglium L., have been used for the treatment of gastrointestinal disturbance in Asia. In this study, the effect of the ethanol extrac...
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Matrix metalloproteinase (MMP)-9 degrades type IV collagen in the basement membrane and plays crucial roles in several pathological implications, including tumorigenesis and inflammation. In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol efficiently decreased MMP-9 sec...
متن کاملTransient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate.
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has been shown in cell cultures to enhance the frequency of resistance to methotrexate. However, we found that TPA could also partially protect human KB cells over a short time (72 h) from the cytotoxicity of several antitumor agents, including 4'-demethylepipodophyllotoxin 9-(4,6-O-ethylidene)-beta-D-glucopyranoside (VP-16), vincris...
متن کاملDifferentiation of Human Leukemias in Response to 12 - O - Tetradecanoylphorbol - 13 - Acetate In Vitro
Leukemic cells from patients with acute myeloid leukemia underwent morphological. functional. and histochemical changes within 24-48 hr after treatment with 1 .6 x iO’ M 12-0-tetradecanoylphorbol-13-acetate (TPA). The changes included adhesion to the plastic substrate. a 4-6-fold increase in the number of phagocytic cells, and an increase in the number of alpha-naphthyl-acetate esterase (a-NAE)...
متن کاملMetabolism of tritium-labeled 12-O-tetradecanoylphorbol-13-acetate by cells in culture.
The metabolism of [20-3H]-12-O-tetradecanoylphorbol-13-acetate ([3H]TPA) was studied in human and hamster cell cultures. Within 2 to 3 days after its addition to growing or confluent cultures of hamster embryo fibroblasts, no unchanged [3H]TPA remained in the medium as determined by thin-layer chromatography of the chloroform phase obtained by extraction of the medium with chloroform:methanol:H...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2016
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v15i10.2